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Dr. Grace Holloway was a cardiologist in 1999 San Francisco. hospital. Grace first encountered the Doctor as an emergency patient, when he was fighting for his life after being cut down by a hail of bullets. Although she did her best to save him, Grace was confused by his alien anatomy and he died on the operating table.

Described by the Doctor as "tired of life but afraid of death", she is clearly a cheerful and warm individual but these characteristics are masked beneath a cold, distant veneer of professionalism. Devoted more to her goal in life to "hold back death" rather than her occupation itself, Grace demonstrates a streak of individuality and initiative, though she lacks true confidence in herself.

He regenerates, though more from the reaction to the treatment he is given than to his original condition. He ends up taking Dr. Holloway along with him as he attempts to foil the Master's latest plot. After defeating the Master the Doctor ask her to travel with him but she opts to remain on Earth.

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Daphne Ashbrook comes from a theatrical family in San Diego. Her father is head of Palomar College's drama department, and her mother is a teacher who still acts in local theater. Her sister Taylor and brother Dana are also actors. Dana played Bobby Briggs in the series Twin Peaks.

It was through Daphne that her brother Dana got his first professional break. She urged her agent to come to San Diego to see her brother in a high school production. The agent signed Dana up, and he made his television debut in an episode of "Cagney & Lacey."

Daphne has appeared in both television and movies. She is best known to science fiction fans as "Ensign Melora Pazlar" from the "Star Trek: Deep Space Nine" second season episode "Melora."

Melora was a beautiful and strong-minded but wheelchair-bound woman, whom Doctor Bashir falls in love with. Doctor Bashir tries to help her, but she decides that she is better off as she is.

Daphne has also had staring roles in the films "Dumbarton Bridge" 1999, "Automatic" 1995, "Dead Man's Revenge" 1993, "Sunset Heat" 1992, "Intruders" 1992, and her first staring role in the 1986 movie "Quiet Cool."

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